Mac and Cheese Meatloaf Casserole

The Ultimate Comfort Food Mashup

Mac and Cheese Meatloaf Casserole is the kind of dish that instantly brings comfort, nostalgia, and satisfaction to the table. It combines two beloved American classics—juicy, savory meatloaf and ultra-creamy macaroni and cheese—into one hearty, oven-baked casserole that feels both familiar and exciting. This recipe is perfect for busy weeknights, cozy family dinners, potlucks, or anytime you’re craving something warm, cheesy, and deeply comforting.

What makes this Mac and Cheese Meatloaf Casserole so special is the contrast of textures and flavors. The meatloaf base is tender and well-seasoned, providing a rich, savory foundation. On top sits a luscious layer of homemade mac and cheese, baked until bubbly and lightly golden, with pockets of melted cheddar in every bite. It’s easy to prepare, kid-approved, and endlessly customizable—making it a guaranteed crowd-pleaser.

This dish is more than just a casserole; it’s a comfort food mashup that brings everyone back for seconds.

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Why You’ll Love This Mac and Cheese Meatloaf Casserole

There are countless reasons this Mac and Cheese Meatloaf Casserole deserves a permanent spot in your dinner rotation:

• Two classics in one dish – You get the best of both worlds: hearty meatloaf and creamy mac and cheese.

• Family-friendly – Kids love the cheesy topping, adults love the savory meatloaf.

• Easy to make – Simple ingredients and straightforward steps.

• Perfect for leftovers – Tastes just as good (if not better) the next day.

• Budget-friendly – Made with pantry staples and affordable ingredients.

• Customizable – Add vegetables, switch cheeses, or adjust seasonings to your taste.

• Ideal for gatherings – Great for potlucks, holidays, and casual get-togethers.

If comfort food had a definition, this casserole would be it.

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Recipe Details

• Prep Time: 15 minutes

• Cook Time: 45 minutes

• Total Time: 1 hour

• Yield: Serves approximately 6

• Category: Main Dish

• Method: Baking

• Cuisine: American

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Ingredients Breakdown

Meatloaf Layer

• 1 lb ground beef – Use 80/20 for the best balance of flavor and juiciness.

• ½ cup diced onion – Adds moisture and savory depth.

• ½ cup breadcrumbs – Helps bind the meatloaf and keep it tender.

• 1 large egg – Essential for structure and binding.

• ¼ cup milk – Keeps the meatloaf moist.

• 1 tsp salt – Enhances all the flavors.

• ½ tsp black pepper – Adds gentle warmth and seasoning.

Mac and Cheese Layer

• 2 cups uncooked macaroni – Classic elbow macaroni works best.

• 2 tbsp butter – The base of the cheese sauce.

• 2 tbsp all-purpose flour – Thickens the sauce.

• 2 cups milk – Creates a creamy, smooth texture.

• 2 cups shredded cheddar cheese (divided) – Sharp or medium cheddar both work well.

• ½ tsp paprika – Adds subtle warmth and color.

• ½ tsp dry mustard – Enhances the cheese flavor without overpowering it.

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Step-by-Step Instructions

Step 1: Prepare the Meatloaf

Preheat your oven to 350°F (175°C) and lightly grease a baking dish.

In a large mixing bowl, combine the ground beef, diced onion, breadcrumbs, egg, milk, salt, and black pepper. Gently mix everything together just until combined. Avoid overmixing—this is key to keeping the meatloaf tender.

Press the meat mixture evenly into the bottom of the prepared baking dish, forming a uniform layer.

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Step 2: Bake the Meatloaf

Place the dish in the oven and bake the meatloaf layer for 20 minutes. This initial bake allows the meatloaf to set and release excess fat before adding the mac and cheese layer.

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Step 3: Cook the Macaroni

While the meatloaf is baking, bring a large pot of salted water to a boil. Cook the macaroni according to package instructions until just al dente. Drain and set aside.

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Step 4: Make the Cheese Sauce

In a medium saucepan over medium heat, melt the butter. Stir in the flour and cook for about 1 minute, stirring constantly, to remove the raw flour taste.

Gradually whisk in the milk, continuing to stir until the sauce thickens and becomes smooth. Season with salt, pepper, paprika, and dry mustard.

Remove from heat and stir in 1½ cups of the shredded cheddar cheese, mixing until fully melted and silky.

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Step 5: Assemble the Casserole

Fold the cooked macaroni into the cheese sauce until evenly coated.

Carefully remove the meatloaf from the oven. Spread the mac and cheese mixture evenly over the top of the meatloaf layer. Sprinkle the remaining ½ cup of cheddar cheese on top.

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Step 6: Final Bake

Return the casserole to the oven and bake for 25 minutes, or until the cheese is bubbly and lightly golden on top.

Allow the dish to rest for 5–10 minutes before slicing and serving. This helps the layers hold together beautifully.

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Helpful Tips for Success

• Don’t overmix the meatloaf: Overworking the meat can make it dense and tough.

• Shred your own cheese: Pre-shredded cheese contains anti-caking agents that can affect meltability.

• Season every layer: Proper seasoning ensures the entire dish is flavorful.

• Let it rest: This helps the casserole set and makes cleaner slices.

• Use a deep baking dish: Prevents overflow and keeps layers intact.

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Delicious Variations

Cheesy Variations

• Swap cheddar for Colby Jack, Monterey Jack, or a cheddar blend.

• Add a handful of Parmesan for extra depth.

Protein Options

• Use ground turkey or ground chicken for a lighter version.

• Mix beef with ground pork for richer flavor.

Veggie Add-Ins

• Stir peas, corn, or finely chopped spinach into the mac and cheese.

• Add grated carrots or zucchini to the meatloaf for hidden veggies.

Crunchy Topping

• Sprinkle buttered breadcrumbs or crushed crackers over the top before the final bake.

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Make-Ahead and Storage Instructions

Make Ahead

Assemble the casserole up to 24 hours in advance, cover tightly, and refrigerate. Bake when ready, adding 5–10 extra minutes to the cooking time.

Storage

• Refrigerate leftovers in an airtight container for up to 4 days.

• Freeze individual portions for up to 2 months.

Reheating

• Reheat in the oven at 325°F until warmed through.

• Microwave individual servings in 30-second intervals.

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What to Serve with Mac and Cheese Meatloaf Casserole

This rich dish pairs well with lighter sides:

• Simple green salad with vinaigrette

• Steamed green beans or broccoli

• Roasted carrots or Brussels sprouts

• Garlic bread or dinner rolls

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Nutrition (Per Serving – Approximate)

• Calories: 360 kcal

• Protein: 24 g

• Fat: 18 g

• Saturated Fat: 8 g

• Carbohydrates: 30 g

• Fiber: 2 g

• Sugar: 3 g

• Cholesterol: 95 mg

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Frequently Asked Questions

Can I use boxed mac and cheese?

Yes, but homemade cheese sauce gives the best flavor and texture.

Can I double this recipe?

Absolutely—use a larger baking dish and extend baking time slightly.

Is this kid-friendly?

Very! It’s one of the most popular comfort meals for families.

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Final Thoughts

Mac and Cheese Meatloaf Casserole is the ultimate comfort food mashup—a dish that feels warm, familiar, and incredibly satisfying. It combines the nostalgic flavors of classic meatloaf with the indulgent creaminess of homemade mac and cheese, all baked together into one irresistible casserole. Whether you’re cooking for your family, feeding a crowd, or simply craving something cozy, this recipe delivers every time.

What truly sets this Mac and Cheese Meatloaf Casserole apart is its versatility. You can keep it classic, dress it up with gourmet cheeses, sneak in vegetables, or make it ahead for stress-free dinners. It’s the kind of recipe that becomes a household favorite—one that gets requested again and again.